RIDDLE

The First is 4th from the Last.
The Last is 4th from the First.
The Second is 9th from the First
The Second-Last is 9th from the Last
The Third is the Last and the Fourth is the First.

SOLUTION
The riddle refers to the alphabet and the letters in the word WIZARD.

The  First letter of WIZARD is 4th from the Last letter of the alphabet.
The Last letter of WIZARD is 4th from the First letter of the alphabet.

The Second letter of WIZARD is 9th from the First letter of the alphabet.
The Second Last letter of WIZARD is 9th from the Last letter of the alphabet.

The Third letter of WIZARD is the Last letter of the alphabet.
The Fourth letter of WIZARD is the First letter of the alphabet.